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Home - Products - GPCR/G Protein - Chemokine Receptor - AF-399 42016530

AF-399 42016530

CAS No. 618864-56-5

AF-399 42016530( AF-399/42016530 )

Catalog No. M15341 CAS No. 618864-56-5

A potent CCR4 antagonist that blocked CCL22- and CCL17-mediated migration of human peripheral blood CD4+CD25+ Treg and Th2 cells ex-vivo and murine Tregs in-vivo.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    AF-399 42016530
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent CCR4 antagonist that blocked CCL22- and CCL17-mediated migration of human peripheral blood CD4+CD25+ Treg and Th2 cells ex-vivo and murine Tregs in-vivo.
  • Description
    A potent CCR4 antagonist that blocked CCL22- and CCL17-mediated migration of human peripheral blood CD4+CD25+ Treg and Th2 cells ex-vivo and murine Tregs in-vivo; enhances DC-mediated human CD4(+) T cell proliferation in an in vitro immune response model and amplifies cellular and humoral immune responses in vivo in experimental models, induces antigen-specific CD8+ T cells and tumor immunity against self antigens in combination with vaccines.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    AF-399/42016530
  • Pathway
    GPCR/G Protein
  • Target
    Chemokine Receptor
  • Recptor
    Chemokine Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    618864-56-5
  • Formula Weight
    531.619
  • Molecular Formula
    C26H17N3O4S3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    4-(1-benzofuran-2-ylcarbonyl)-1-[5-(benzylsulfanyl)-1,3,4-thiadiazol-2-yl]-3-hydroxy-5-(2-thienyl)-1,5-dihydro-2H-pyrrol-2-one.

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Klein A, et al. Oncotarget. 2017 May 9;8(19):31079-31091. 2. Bayry J, et al. Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):10221-6. 3. Pere H, et al. Blood. 2011 Nov 3;118(18):4853-62.
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